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Brainstem inflammation was found in the areas of the cardiorespiratory control centers. Poly I:C injection led to a biphasic increase in rectal temperature and heart rate associated with an overall decrease in heart-rate variability, with no change in respiratory-rate variability. Provides unique observations on the cardiorespiratory consequences of injecting Poly I:C in a full-term newborn lamb to mimic a systemic inflammation secondary to a viral sepsis.
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Although further studies are obviously needed, this might be a way to differentiate bacterial from viral sepsis in the neonatal period. Meanwhile, the absence of alterations in respiratory-rate variability is intriguing and noteworthy. The alterations in heart-rate variability induced by Poly I:C injection may be, at least partly, of central origin. Lastly, brainstem inflammation was found in the areas of the cardiorespiratory control centers 6 h after Poly I:C injection.
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The latter was associated with an overall decrease in heart-rate variability, with no change in respiratory-rate variability. It also led to a biphasic increase in rectal temperature and heart rate. Poly I:C injection decreased locomotor activity and increased NREM sleep. Two 6-h polysomnographic recordings were carried out in eight lambs on two consecutive days, first after an IV saline injection, then after an IV injection of 300 μg/kg Poly I:C. We aimed to characterize these alterations by setting up a full-term newborn lamb model of systemic inflammation using polyinosinic:polycytidylic acid (Poly I:C). The link between systemic inflammation with viral sepsis and cardiorespiratory alterations remains poorly understood.
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Prior to joining Ashfords, Katie led the led the health and welfare team within Foot Anstey’s mental capacity practice. In addition, Katie regularly provides training to charities and public bodies regarding their mental capacity policies and the implementation of changes in the law. She also has experience in seeking damages for breaches of the Human Rights Act. Katie routinely provides advice and representation in relation to deprivation of liberty issues and wider community care issues. Katie is a specialist practitioner with extensive experience representing individuals who lack capacity (both on the instruction of the Official Solicitor and Independent Mental Capacity Advocates) as well as family members, care homes and healthcare organisations in complex health and welfare proceedings before the Court of Protection. Katie is a Partner and leads the Court of Protection team.
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